Hyperpolarized 129Xe MRI: A viable functional lung imaging modality?
نویسندگان
چکیده
منابع مشابه
Functional lung imaging using hyperpolarized gas MRI.
The noninvasive assessment of lung function using imaging is increasingly of interest for the study of lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma. Hyperpolarized gas MRI (HP MRI) has demonstrated the ability to detect changes in ventilation, perfusion, and lung microstructure that appear to be associated with both normal lung development and disease progres...
متن کاملFast dynamic ventilation MRI of hyperpolarized 129Xe using spiral imaging
PURPOSE To develop and optimize a rapid dynamic hyperpolarized 129 Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS Spiral k-space trajectories were designed with the number of interleaves Nint = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of...
متن کاملRF Coils Design for Small Animal MRI Lung Imaging at 3T Using Hyperpolarized 129Xe and Inert Fluorinated Gases
............................................................................................................................ 2 ACKNOWLEDGEMENT ...................................................................................................... 3 LIST OF FIGURES ................................................................................................................ 6 LIST OF TABLES ......
متن کاملQuantification of human lung structure and physiology using hyperpolarized 129Xe.
PURPOSE To present in vivo, human validation of a previously proposed method to measure key pulmonary parameters related to lung microstructure and physiology. Some parameters, such as blood-air barrier thickness, cannot be measured readily by any other noninvasive modality. METHODS Healthy volunteers (n = 12) were studied in 1.5T and 3T whole body human scanners using hyperpolarized xenon. X...
متن کاملHyperpolarized 129Xe MR Imaging of Alveolar Gas Uptake in Humans
BACKGROUND One of the central physiological functions of the lungs is to transfer inhaled gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange. METHODS AND PRINCIPAL FINDINGS Here we exploit the solubility, hig...
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ژورنال
عنوان ژورنال: European Journal of Radiology
سال: 2007
ISSN: 0720-048X
DOI: 10.1016/j.ejrad.2007.08.008